Our work centers on RNA structure and recognition to advance RNA-targeted drug discovery.

RNA Structural Biology

We determine high-resolution structures of disease-associated noncoding RNAs—both alone and in complex with proteins or small molecules—using an integrative structural biology approach. Our methods include cryo-electron microscopy (cryo-EM), NMR spectroscopy, X-ray crystallography, and biochemical assays.

RNA Recognition by Proteins or Small Molecules in Disease

We investigate how RNA-binding proteins and small molecules recognize pathogenic RNAs to uncover the molecular mechanisms underlying RNA-driven diseases. Our goal is to understand these interactions in detail and harness this knowledge to inform the design of more effective RNA-targeted therapeutics.

RNA Dynamics and Mechanism

We study the conformational flexibility and dynamic behavior of RNAs to reveal how RNA motions influence molecular recognition, biological function, and disease processes.

Structure-Based RNA Therapeutics

We develop and characterize small molecules and antisense oligonucleotides that selectively bind to structured RNAs or disrupt toxic RNA–protein interactions, aiming to inform and advance RNA-targeted drug discovery.