*co-first authors; #corresponding authors [Google Scholar]

PREPRINTS

Yang Y, Murrali MG, Wang Y, Galvan S, Ajjampore N, and Feigon J, HEXIM1 homodimer binds two sites on 7SK RNA to release autoinhibition for P-TEFb inactivation, bioRxiv 2024 [bioRxiv] [PDF]

2026

2025 AND BEFORE

Selective publications:

  1. Wang Y*, He Y*, Wang Y*, Yang Y*, Singh M, Eichhorn C, Cheng X, Jiang YX, Zhou ZH, and Feigon J, Structure of LARP7 protein p65–telomerase RNA complex in telomerase revealed by cryo-EM and NMR, Journal of Molecular Biology, 2023, 435:168044. [Full text] [Pubmed] [PDF]
  2. Wang Y, Gallagher-Jones M, Sušac L, Song H, and Feigon J, A structurally conserved human and Tetrahymena telomerase catalytic core, Proceedings of the National Academy of Sciences of the United States of America, 2020, 117(49):31078-31087
  3. Jiang J*, Wang Y*, Sušac L*, Chan H, Basu R, Zhou ZH, and Feigon J, Structure of Telomerase with Telomeric DNA, Cell. 2018, 173:1179-1190.e13. (Featured in F1000, UCLA Newsroom, and PDB Molecule of the Month)
  4. Wang Y, Yesselman JD, Zhang Q, Kang M, and Feigon J, Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human, Proceedings of the National Academy of Sciences of the United States of America, 2016, 113(35):E5125-34

Full list:

  1. Wang Y*, He Y*, Wang Y*, Yang Y*, Singh M, Eichhorn C, Cheng X, Jiang YX, Zhou ZH, and Feigon J, Structure of LARP7 protein p65–telomerase RNA complex in telomerase revealed by cryo-EM and NMR, Journal of Molecular Biology, 2023, 435:168044. [Full text] [Pubmed] [PDF]
  2. He Y*, Song H*, Chan H, Liu B, Wang Y, Susac L, Zhou ZH, and Feigon J, Structure of Tetrahymena telomerase-bound CST with polymerase α-primase. Nature, 2022, 608:813-818
  3. Liu B, He Y, Wang Y, Song H, Zhou ZH, and Feigon J, Structure of active human telomerase with telomere shelterin protein TPP1, Nature, 2022, 604:578-583
  4. Lu X, Li M, Arce FA, Ling J, Setiawan N, Wang Y, Shi X, Campbell HR, Nethercott MJ, Xu W, Munson EJ, Marsac PJ, and Su Y, Mechanistic Investigation of Drug Supersaturation in the Presence of Polysorbates as Solubilizing Additives by Solution Nuclear Magnetic Resonance Spectroscopy, Mol Pharm, 2021, 18(12):4310-4321
  5. He Y, Wang Y, Liu B, Helmling C, Sušac L, Cheng R, Zhou ZH, and Feigon J, Structures of telomerase at multiple steps of telomere repeat synthesis, Nature, 2021, 593:454-459
  6. Wang Y, Gallagher-Jones M, Sušac L, Song H, and Feigon J, A structurally conserved human and Tetrahymena telomerase catalytic core, Proceedings of the National Academy of Sciences of the United States of America, 2020, 117(49):31078-31087
  7. Wang Y, Sušac L, and Feigon J, Structural Biology of Telomerase, Cold Spring Harbor Perspectives in Biology, 2019, 11(12). pii: a032383 (a chapter of RNA Worlds: New Tools for Deep Exploration)
  8. Yang Y, Eichhorn CD, Wang Y, Cascio D, and Feigon J, Structural basis of 7SK RNA 5’ γ-phosphate methylation and retention by MePCE, Nature Chemical Biology, 2019, 15:132–140
  9. Jiang J*, Wang Y*, Sušac L*, Chan H, Basu R, Zhou ZH, and Feigon J, Structure of Telomerase with Telomeric DNA, Cell. 2018, 173:1179-1190.e13. (Featured in F1000, UCLA Newsroom, and PDB Molecule of the Month)
  10. Wang Y and Feigon J, Structural biology of telomerase and its interaction at telomeres, Current Opinion in Structure Biology. 2017, 18;47:77-87
  11. Chan H*, Wang Y*, Feigon J, Progress in Human and Tetrahymena Telomerase Structure, Annual Review in Biophysics, 2017, 46:199–225
  12. Wang Y, Yesselman JD, Zhang Q, Kang M, and Feigon J, Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human, Proceedings of the National Academy of Sciences of the United States of America, 2016, 113(35):E5125-34
  13. Shen K, Wang Y, Fu Y, Zhang Q, Feigon J, and Shan SO, Molecular mechanism of GTPase activation at the SRP RNA distal end, Journal of Biological Chemistry, 2013, 288(51):36385-97.
  14. Wang Y, Sarkar M, Smith A, Krois AS, Pielak GJ, Macromolecular crowding and protein stability, Journal of the American Chemical Society, 2012, 134(40): 16614-8 (Featured in JACS Spotlights)
  15. Wang Y, Benton LA, Singh V, Pielak GJ, Disordered protein diffusion under crowded conditions, Journal of Physical Chemistry Letters, 2012, 3(18): 2703-6.
  16. Wang Y, Li C, Pielak GJ, In-cell magnetic resonance spectroscopy, Chinese Journal of Magnetic Resonance, 2012, 29(4): 475-88.
  17. Schlesinger A, Wang Y, Tadeo X, Millet O, Pielak GJ, Macromolecular crowding fails to fold a globular protein in cells, Journal of the American Chemical Society, 2011, 133(21):8082-5.
  18. Miklos A, Sarkar M, Wang Y, Pielak GJ, Protein Crowding Tunes Protein Stability, Journal of the American Chemical Society, 2011, 133(18):7116-20 (Featured in F1000, JACS Select, and NSF SEE Innovation)
  19. Wang Y, Li C, Pielak GJ, Effects of Proteins on protein diffusion, Journal of the American Chemical Society, 2010, 132(27):9392-7.
  20. Li C, Wang GF, Wang Y, Creager-Allen R, Lutz EA, Scronce H, Slade KM, Ruf RA, Mehl R, Pielak GJ, Protein 19F NMR in Escherichia coli, Journal of the American Chemical Society, 2010, 132(1):321-7 (Featured in C&EN).
  21. Li C, Wang Y, Pielak GJ, Translational and rotational diffusion of a small globular protein under crowded conditions, Journal of Physical Chemistry B, 2009, 113(40):13390-2.
  22. Li CX*, Wang Y*, Gao H, Pan WJ, Xiang Y, Huang M, Lei H, Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution 1H magnetic resonance spectroscopy, Neurochemical Research, 2008, 33(11):2342-9
  23. Gao HC, Xiang Y, Sun NL, Zhu H, Wang Y, Liu ML, Ma YY, Lei H, Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied by ex vivo high resolution 1H NMR spectroscopy, Neurochemistry International, 2007, 50(2):386-94

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